THE PATHOGENESIS OF ICTERUS

The Pathogenesis of Icterus

These experiments indicate that, in obstructive jaundice, the bile which escapes from the liver is absorbed by the hepatic capillaries and carried by the blood to the kidneys. The presence of a thoracic duct fistula influences in no way the development of icterus after total obstruction of the common bile duct. Bile pigments, sufficient to give a Salkowski test, may or may not appear in the lym...

Icterus

The intravenous injection of red cells obtained from the same animal and laked by distilled water is similar to certain types of hemolysis which result in hematogenous jaundice. This procedure cannot be criticized on the grounds of introducing toxic substances. The hemoglobin circulating in the blood stream is rapidly changed, in part at least, to bile pigment. The change goes on with practical...

Icterus

It is known that hemoglobin can be rapidly changed to bile pigment in a circulation confined to the head, neck, and thorax. This excludes direct liver participation (1). These experiments show that hemoglobin can be changed to bile pigment within the pleural or peritoneal cavities. This transformation can usually be detected after eight hours, and the amount can often be estimated quantitativel...

Insufficient glucuronide formation in the newborn and its relationship to the pathogenesis of icterus neonatorum.

In the last few years the pathogenesis of icterus neonatorum and kernikterus has aroused renewed interest (Napp and Plotz, 1949; Obrinsky, Allen and Anderson, 1954; Billing, Cole and Lathe, 1954; Meyer, 1956). The discovery by Schmid (1956) and Billing, Cole and Lathe (1957) that bilirubin is excreted in the bile as a glucuronide now makes it possible to reinvestigate this problem more specific...

The Immunological Basis in the Pathogenesis of Gout